Table 1.

Summary of the animal models used to assess the effects of estrogen on HSP expression. Species, strain, age, and length of time of E2 replacement following ovariectomy, as well as the reported change in HSP 72 expression are reported.

	Species	Strain	Age	Ovxa to Study	HSP 72
Bupha-Intr et al. 2004 (103)	Rat	SD	8–9 weeks	9 weeks	20% decrease HSP 72 with ovx by Western
Fekete et al. 2006 (98)	Rat	N/A	N/A	Intact	F > M post Ischemia/Reperfusion
Nickerson et al. 2006 (102)	Rat	F344	N/A	Intact	Female 0.46 versus male 0.4 pg/μg HSP 72 ELISA
Papacontantinou et al. 2003 (94)	Mouse	N/A	N/A	4 days SC E2 0.02mg/mL	Ovx 66% decrease
Paroo et al. 2002 (101)	Rat	SD	N/A	Intact	Estrogen blocked exercise–associated increase HSP 72
Shinohara et al. 2004 (105)	Rat	SD	10 weeks	1 week	Ovx no effect HSP 72
Thawornkaiwong et al. 2007 (104)	Rat	SD	8–9 weeks	10 weeks SC E2	Ovx 27% decrease in HSP 72
Voss et al. 2003 (95)	Rat	SD	12–16 weeks	9 weeks	Female 29 pg/μg at peak estrus versus male 14 pg/μg; ovx 9 weeks to male

^aOvariectomized