Table 1. Multiple sequence alignment of thioaptamer candidates.
42 sequences isolated independently at 18th round of selection were aligned using ClustalW algorithm. Number in the parenthesis indicates number of sequence. A and C, 5′ side of which are phosphorothioates, are in bold characters.
| Name | Sequence | |
|---|---|---|
| T18_1_3 | (11) | --TGTCGT--TGT--GTC--CTGTACCCG--CCTTGACCA- |
| T18_1_2 | (1) | TGTCTCGA--TGCTAGACT-CTATACCCG--CCAA------ |
| T18_1_1 | (1) | --TGTGGAC-TG---GTCT-ATCCATGCA--CCTGTACC-- |
| T18_1_8 | (1) | TGTGT-GTA-TG---GTCC-TTGCATCGATTCCCTG----- |
| T18_2_13 | (1) | --TGT-GTC-TA----TCG-CTGCACCGTGTCCAT-ACA-- |
| T18_2_15 | (1) | ---GT-GTG-CGTT-GTC---TGT--CCGTTTCCTGTCCAC |
| T18_2_10 | (1) | TGTGGCGT--TGAT-ATCGACTGT-------CCTTG-CCAC |
| T18_1_11 | (2) | TTGGTTGA--TGTGCATCG-CTGT-------TCCTGTCCA- |
| T18_1_4 | (1) | TGGGTCGC--TG---ATC----GCATCGATACTCT--CCAC |
| T18_1_24 | (1) | ATCGTCGAC-TG----TC--CTGTCACTGT-CCAT--CCA- |
| T18_2_2 | (15) | --TGGAGG--TGCCTGGA---TATATC-GA--CTCGACCC- |
| T18_1_10 | (1) | -GTGTCCT--TGTCTAGCCTCGATA-------CACGACAC- |
| T18_1_23 | (1) | TGTGGCGT--TG----AC---TGTACACGTCGATACACC-- |
| T18_1_19 | (1) | --TGGCTGG-TCACTGTA--CTCT--CTGC-TCTCCAC--- |
| T18_1_13 | (1) | --TGTAGTG-TCC-TGGC---TATCCACGT--CTCCATT-- |
| T18_1_18 | (1) | ----TGGAT-CGCTTATCGCCTCGATC-----ATTGCCCA- |
| T18_1_15 | (1) | -TTGTTGTACTGGC-ATCGCCTCGACTCG---CTG------ |
| consensus | TGT GA TG GTC CTGTA C G CT GACC |