Table 6.
Marginal means for intravenous glucose tolerance measures
| SNP | Utah Caucasian Family samples | Arkansas Caucasian population | |||||||
| rs10847 | CC | CT | TT | p-value | CC | CT | TT | p-value | |
| n | 68 | 47 | 10 | 124 | 85 | 21 | |||
| SI | 5.66 (4.29,7.48) | 6.14 (4.64,8.11) | 7.75 (1.84,32.64) | 0.84 | 4.85 (4.11, 5.71) | 5.45 (4.47, 6.63) | 5.42 (3.58, 8.18) | 0.64 | |
| AIRg | 116 (93,145) | 152 (122,190) | 249 (81,757) | 0.09 | 2370 (2082,2694)) | 2142 (1830,2502) | 1890 (1380,2580) | 0.32 | |
| DI | 0.99 (0.59,1.66) | 1.29 (0.77,2.16) | 1.55 (0.42,5.68) | 0.5 | 1152 (969,1371) | 1173 (951,1447) | 1111 (716,1725) | 0.37 | |
| rs188970 | CC | CT | TT | p-value | CC | CT | TT | p-value | |
| n | 48 | 51 | 23 | 87 | 103 | 32 | |||
| SI | 5.29 (4.11,6.81) | 6.40 (4.83,8.46) | 6.45 (4.27,9.73) | 0.49 | 5.68 (5.07, 6.37) | 5.40 (4.85, 6.00) | 5.70 (4.68, 6.93) | 0.11 | |
| AIRg | 200 (163,246) | 141 (113,177) | 115 (82,159) | 0.005 | 2388 (2046,2784) | 2082 (1806,2400) | 2664 (2052, 3468) | 0.18 | |
| DI | 1.25 (0.76,2.06) | 1.13 (0.65,1.97) | 1.07 (0.47,2.42) | 0.91 | 1356 (1170,1573) | 1122 (979,1287) | 1520 (1180,1958) | 0.37 | |
| rs2134688 | TT | TC+CC | p-value | TT | TC+CC | p-value | |||
| n | 96 | 26 | 193 | 36 | |||||
| SI | 6.62 (6.21,8.41) | 5.80 (3.56,9.45) | 0.86 | 5.48 (5.05,6.37) | 5.38 (4.43, 6.52) | 0.86 | |||
| AIRg | 164 (134, 200) | 132 (88, 197) | 0.31 | 2244 (2022,2490) | 2280 (1788,2910) | 0.66 | |||
| DI | 1.33 (0.91,1.95) | 1.07 (0.59,1.93) | 0.5 | 1132 (987,1299) | 1201 (867,1633) | 0.94 | |||
| rs11204735 | GG | GA | AA | p-value | GG | GA | AA | p-value | |
| n | 34 | 53 | 31 | 66 | 115 | 48 | |||
| SI | 5.49 (3.90,7.72) | 6.28 (4.70,8.39) | 4.92 (3.61,6.71) | 0.46 | 5.60 (4.88, 6.45) | 5.22 (4.70, 5.78) | 5.52 (4.68, 6.52) | 0.66 | |
| AIRg | 117 (89,152) | 150 (119,188) | 216 (169,277) | 0.002 | 2370 (1986,2832) | 2220 (1944,2538) | 2190 (1776,2700) | 0.8 | |
| DI | 0.71 (0.38,132) | 1.36 (0.81,230) | 1.36 (0.78,2.38) | 0.14 | 1328 (1112,1587) | 1157 (1012,1322) | 1209 (980,1492) | 0.46 | |
Marginal means are shown after adjustment for age, gender and BMI; significance is based on a general linear model and p values are shown without correction for multiple testing. AIRg in the Utah Caucasian study is from the mean 2–10 min post challenge insulin excursion in pmol/l; for Arkansas Caucasian study, the AIRg is taken from MinMod Millenium output and is the area under the curve from 0 to 10 min, converted to pmol/l. All means are transformed back to the linear scale from Ln-transformed values; 95% confidence intervals are provided in parenthesis. SI, insulin sensitivity index from MinMod in (pmol/l) min-1; AIRg, acute 2–10 min insulin response to intravenous glucose bolus, in pmol/l (UT sample) or pmol-min/l (AR sample); DI, Disposition index (SI × AIRg) has no units. Values from the Utah sample are × 10-2. Note that the MinMod Millenium program calculates disposition index using the area under curve for AIRg and without the decimal places for SI (10-5 (pmol/l) min-1. Because calculations in the Utah population used mean 2 min – 10 min insulin to calculate AIRg and calculated SI × AIRg values were calculated using the legacy MinMod program and Arkansas samples using the MinMod Millenium program, the values between populations are not directly comparable.