Table 2.
Association between skin type and lymphoid malignancy (LM) (NHL: non-Hodgkin’s lymphoma; HL: Hodgkin’s lymphoma; LPS: lymphoproliferative syndrome; MM: multiple myeloma) – ORs were estimated by unconditional logistic regression adjusted for stratification variables.
| All LM
|
NHL
|
HL
|
LPS
|
MM
|
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases n=813 | Controls n=748 | OR [95%CI] | Cases n=395 | Controls n=698 | OR [95%CI] | Cases n=147 | Controls n=415 | OR [95%CI] | Cases n=168 | Controls n=464 | OR [95%CI] | Cases n=103 | Controls n=476 | OR [95%CI] | ||||||
| Eye color | ||||||||||||||||||||
| Blue/gray/green | 398 | 359 | 1.0 | [0.8–1.3] | 179 | 334 | 0.9 | [0.7–1.2] | 69 | 184 | 1.1 | [0.7–1.6] | 100 | 238 | 1.3 | [0.9–1.9] | 50 | 234 | 1.0 | [0.6–1.6] |
| Hazel/brown/black | 412 | 386 | 1.0 | ref. | 215 | 361 | 1.0 | ref. | 78 | 231 | 1.0 | ref. | 67 | 223 | 1.0 | ref. | 52 | 239 | 1.0 | ref. |
| Hair color | ||||||||||||||||||||
| Blond/red | 73 | 57 | 1.2 | [0.8–1.7] | 33 | 53 | 1.1 | [0.7–1.8] | 14 | 22 | 1.8 | [0.8–3.8] | 16 | 39 | 1.1 | [0.6–2.1] | 10 | 40 | 1.1 | [0.5–2.3] |
| Light brown/dark brown/black | 738 | 687 | 1.0 | ref. | 362 | 641 | 1.0 | ref. | 132 | 392 | 1.0 | ref. | 151 | 422 | 1.0 | ref. | 93 | 433 | 1.0 | ref. |
| Skin color | ||||||||||||||||||||
| Very fair/fair | 585 | 512 | 1.2 | [0.9–1.5] | 281 | 478 | 1.1 | [0.8–1.5] | 112 | 281 | 1.6 | [1.0–2.5] | 118 | 323 | 1.1 | [0.7–1.7] | 74 | 325 | 1.1 | [0.7–1.9] |
| Olive/brown | 224 | 233 | 1.0 | ref. | 113 | 217 | 1.0 | ref. | 35 | 134 | 1.0 | ref. | 48 | 138 | 1.0 | ref. | 28 | 148 | 1.0 | ref. |
| Propensity to burn (skin reaction to first unprotected seasonal exposure to sun) | ||||||||||||||||||||
| Severe/painful burn | 398 | 331 | 1.3 | [1.0–1.6]* | 191 | 311 | 1.2 | [0.9–1.6] | 74 | 164 | 1.5 | [1.0–2.2] | 88 | 205 | 1.4 | [1.0–2.1] | 45 | 207 | 1.1 | [0.7–1.7] |
| Burn then tan/tan without burning | 405 | 411 | 1.0 | ref. | 198 | 382 | 1.0 | ref. | 73 | 248 | 1.0 | ref. | 79 | 253 | 1.0 | ref. | 55 | 263 | 1.0 | ref. |
| Ability to tan (skin reaction to repeated exposures to sun) | ||||||||||||||||||||
| None/mild tan | 156 | 127 | 1.2 | [0.9–1.5] | 76 | 121 | 1.1 | [0.8–1.5] | 34 | 64 | 1.7 | [1.0–2.8]* | 30 | 73 | 1.1 | [0.7–1.8] | 16 | 80 | 0.9 | [0.5–1.6] |
| Moderate/deep tan | 648 | 617 | 1.0 | ref. | 315 | 573 | 1.0 | ref. | 113 | 350 | 1.0 | ref. | 136 | 387 | 1.0 | ref. | 84 | 392 | 1.0 | ref. |
| Hair and skin profile | ||||||||||||||||||||
| Blond/red hair +severe/painful burn | 53 | 40 | 1.4 | [0.9–2.1] | 28 | 39 | 1.5 | [0.9–2.5] | 12 | 13 | 3.4 | [1.4–8.4]* | 8 | 28 | 0.9 | [0.4–2.2] | 5 | 27 | 0.9 | [0.3–2.5] |
| Light brown/dark brown/black hair+severe/painful burn | 344 | 290 | 1.3 | [1.0–1.5]* | 163 | 271 | 1.2 | [0.9–1.6] | 61 | 150 | 1.3 | [0.9–2.0] | 80 | 177 | 1.5 | [1.0–2.2]* | 40 | 180 | 1.1 | [0.7–1.8] |
| Burn then tan/Tan without burning | 405 | 411 | 1.0 | ref. | 198 | 382 | 1.0 | ref. | 73 | 248 | 1.0 | ref. | 79 | 253 | 1.0 | ref. | 55 | 263 | 1.0 | ref. |
| p trend | 0.03 | 0.09 | 0.02 | 0.21 | 0.87 | |||||||||||||||
*
p < 0.05 (p-values greater than 0.05 not shown in the table)