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. Author manuscript; available in PMC: 2009 Mar 1.
Published in final edited form as: Neurobiol Aging. 2006 Dec 19;29(3):452–463. doi: 10.1016/j.neurobiolaging.2006.10.026

Fig. 8. The pattern of gene expression detected in the corpus callosum of older mice can be recapitulated in vitro by treating differentiating oligodendrocytes with pharmacological inhibitors of HDAC.

Fig. 8

Panel A: mRNA expression of the indicated transcription factors in RNA samples isolated from primary cultures of oligodendrocyte progenitors maintained proliferating (prog) or differentiated (diff cell) in the absence (-TSA) and presence (+TSA) of pharmacological inhibitor of HDAC. Panel B: Densitometric quantification of the results presented in A (*=p<0.001). Panel C: immunocytochemistry of cells exposed to the same conditions described in panel A and then stained with antibodies specific for Id4 (Objective 40X).