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. Author manuscript; available in PMC: 2008 Apr 20.
Published in final edited form as: Cell. 2008 Mar 21;132(6):958–970. doi: 10.1016/j.cell.2008.01.018

Figure 3. FoxA1 cell type-specific binding sites also recruit nuclear receptors ERα or AR and correlate with regulation of sex steroid signaling in breast and prostate cancer cells.

Figure 3

A) Enrichment for the ERE, ERE half-site, FKHR, ARE and ARE half-site in the center of the binding sites specific to MCF7 cells (MCF7-only) or LNCaP cells (LNCaP-only) or shared between the two cell-lines (Both). The occurrence of the motifs (N motifs) was normalized to the number of sites in each subset (N binding sites). B) Venn diagrams depicting the overlap between FoxA1 (red) and ERα (blue) binding sites from MCF7 cells together with FoxA1 (green) and AR (orange) binding sites from LNCaP cells. C). Correlation between E2 or DHT regulated genes and binding sites for FoxA1 and ERα in MCF7 cells or for FoxA1 and AR in LNCaP cells. Analyses were performed as in Fig.1B using hormone regulated or non-regulated genes from chromosomes 8,11 and 12. Fold change is presented for instances where significant differences are observed between regulated versus non-regulated genes.