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Longitudinal measurements of thermal hyperalgesia in type 1 BB/Wor-rats without and with C-peptide replacement from onset of diabetes compared to duration- and hyperglycemia-matched type 2 BBZDR/Wor-rats and age-matched control rats. Note more severe hyperalgesia in type 1 as compared to type 2 rats and with partial but significant prevention in C-peptide treated rats [48, 49].
