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The effect of type 1 and type 2 diabetes on unmyelinated axonal size (a) and numbers (b) in the sural nerve in 7-8 month diabetic rats. Note in type 1 rats, significant atrophy (a) and loss (b) of unmyelinated fiber, whereas no significant deficits were detectable in type 2 BBZDR/Wor-rats. Replenishment with C-peptide resulted in significant prevention of C-fiber atrophy (a) and loss (b) [17, 47].
