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. 2008 Apr 16;2008:230458. doi: 10.1155/2008/230458

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Copyright © 2008 Anders A. F. Sima et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Expression of the receptors of neurotrophic factors in dorsal root ganglia in 8-month type 1 diabetic (D1) and type 2 diabetic (D2) rats, as well as type 1 rats replaced with C-peptide. (c) compared to age-matched control rats . Note marked decreases in the expression of insulin receptor, IGF-1 receptor, and NGF-TrkA receptor in type 1 rats. These defects were significantly milder in type 2 diabetic rats and were significantly prevented by C-peptide replacement in type 1 diabetic rats [50].