Table 2. Fold change of the expression of selected genes in tumor vs normal liver tissues of mice.
RB Positive Tumors | RB Negative Tumors | |||||||
---|---|---|---|---|---|---|---|---|
Gene | ΔCT Normal | ΔCT Tumor | Fold Change | p value | ΔCT Normal | ΔCT Tumor | Fold Change | p value |
Ahr | 8.2 ± 0.1 | 10.0 ± 0.6 | 0.3 ± 0.2 | 0.004 | 8.8 ± 0.2 | 9.5 ± 0.2 | 0.6 ± 0.1 | <0.001 |
Cdkn1a (p21) | 12.5 ± 0.8 | 10.2 ± 1.4 | 4.9 ± 0.7 | 0.01 | 8.8 ± 3.1 | 8.3 ± 0.5 | 1.4 ± 1.0 | N.S. |
Cdkn1b (p27) | 9.0 ± 0.3 | 9.7 ± 0.7 | 0.6 ± 0.3 | N.S. | 10.2 ± 1.0 | 9.4 ± 0.2 | 1.7 ± 0.3 | N.S. |
Cdkn2b (p15) | 19.7 ± 3.6 | 19.7 ± 3.2 | 1.0 ± 2.0 | N.S. | 18.8 ± 2.0 | 19.1 ± 1.4 | 0.8 ± 0.8 | N.S. |
Cdkn2c (p18) | 11.6 ± 0.2 | 9.5 ± 1.0 | 4.3 ± 0.4 | 0.02 | 12.2 ± 1.5 | 9.5 ± 0.6 | 6.5 ± 0.5 | 0.001 |
Cdkn2d (p19) | 10.3 ± 0.3 | 11.4 ± 0.4 | 0.5 ± 0.2 | 0.01 | 12.4 ± 1.8 | 11.1 ± 0.4 | 2.5 ± 0.6 | N.S. |
Cyp1a1 | 14.2 ± 0.8 | 20.1 ± 4.7 | 0.0 ± 2.0 | N.S. | 20.3 ± 1.4 | 19.0 ± 2.3 | 2.5 ± 0.9 | N.S. |
Dnmt1 | 11.8 ± 0.2 | 12.2 ± 0.7 | 0.8 ± 0.3 | N.S. | 11.2 ± 0.5 | 11.0 ± 0.4 | 1.1 ± 0.2 | N.S. |
Hdac1 | 8.0 ± 0.4 | 8.4 ± 0.3 | 0.8 ± 0.2 | N.S. | 8.6 ± 0.4 | 8.2 ± 0.3 | 1.3 ± 0.2 | N.S. |
Nqo1 | 8.8 ± 0.7 | 9.4 ± 2.1 | 0.7 ± 0.9 | N.S. | 10.4 ± 1.4 | 10.6 ± 1.6 | 0.9 ± 0.7 | N.S. |
Pai1 | 12.6 ± 0.4 | 10.9 ± 1.0 | 3.2 ± 0.4 | <0.001 | 12.1 ± 2.2 | 10.6 ± 1.4 | 2.8 ± 0.8 | N.S. |
Tgfb1 | 8.2 ± 0.1 | 9.4 ± 0.2 | 0.4 ± 0.1 | <0.001 | 8.8 ± 0.5 | 8.4 ± 0.3 | 1.3 ± 0.2 | N.S. |
Tgfb2 | 14.4 ± 1.4 | 11.0 ± 0.5 | 10.6 ± 0.6 | 0.006 | 14.5 ± 1.1 | 11.4 ± 0.8 | 8.6 ± 0.4 | <0.001 |
Tgfb3 | 18.6 ± 1.2 | 15.1 ± 1.0 | 11.3 ± 0.6 | 0.008 | 16.3 ± 1.3 | 15.3 ± 1.2 | 2.0 ± 0.6 | N.S. |
Trp53 | 6.7 ± 0.2 | 6.5 ± 0.6 | 1.1 ± 0.3 | N.S. | 6.3 ± 0.6 | 6.1 ± 0.3 | 1.1 ± 0.2 | N.S. |