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. 2008 Apr 30;3(4):e2069. doi: 10.1371/journal.pone.0002069

Figure 5. Action of ERα and ERβ agonists on insulin content.

Figure 5

(A) Insulin content of islets cultured for 48 hours in the presence of increasing doses of the ERα-selective agonist PPT. The bar labeled E2 represents islets cultured with 1 nM E2 for 48 hours. Note that PPT increases insulin content in an inverted-U dependent manner and its potency is in the same range as E2 (n = 5, 7 mice), * p<0.05. (B) The ERβ-selective agonist DPN has no effect at doses from 0.1–100 nM. The bar labeled E2 represents islets cultured with 1 nM E2 for 48 hours (n = 4, from at least 5 mice), * p<0.05. (C) Insulin content regulation by PPT in the presence and absence of ICI182,780 (n = 4, from at least 6 mice), * p<0.05.