Figure 1.—

CO and NCO frequencies in Mlh3^−/− mice. (A) CO frequencies in wild-type (wt) (+/+ or +/−) and Mlh3^−/− mice during the first wave of spermatogenesis. Values correspond to twice the frequency of BR recombinant molecules and were the average from two measurements at 11 and 13 days and from five to eight measurements at 15, 17, and 19 days. Frequencies are given ± standard error (SE) (blue diamonds, wt; pink squares, Mlh3^−/−). (B) NCO frequencies in wt (+/+ or +/−) and Mlh3^−/− mice during the first wave of spermatogenesis. Values correspond to the frequencies of NCOs with a gene conversion selected at BsrFI on the B6 parental genome and were the average of two, four, and three measurements at 15, 17, and 19 days, respectively. Each frequency measurement was obtained from allele-specific PCR on 96 pools. Frequencies are given ± SE (blue diamonds, wt; pink squares, Mlh3^−/−).