The time between clicks of the ratchet as a function of the ratchet number for simulations with a completely nonrecombining fourth chromosome for simulation parameters: N = 1000, u = 0.01, v = 0, a = 0.001, and b = 0.0003 (A) or b = 0.0004 (B). A shows the results of 30 simulations run for 5 × 105 generations, and B shows the results of 50 simulations run for 106 generations. The line shows the least-squares linear regression.