Table 1.
Summary of animal models of OMa
| Animal species | Chinchilla | Gerbil | Guinea pig | Rat | Mouse |
|---|---|---|---|---|---|
| Pathogen recovery frequency (%):
NTHi SP MC |
> 90 > 90 0 |
> 90 > 09 0 |
NA [53] 100% [54] NA [55] |
> 90 > 90 < 60 |
100 [60] 100 [3] 0 [3] |
| Pathology frequency (%):
NTHi SP MC |
> 90 > 90 < 60 |
> 90 > 90 < 60 |
100 [53] 70 [56] >60 [55] |
> 90 > 90 < 60 |
100 [60] 100 [3,61] 0 [3] |
| Inbred strains | − | + | + | ++ | +++ |
| Genetic mutant models | − | − | − | + | +++ |
| Experimental reagents | − | + | ++ | +++ | +++ |
| Naturally occurring OM | − [50] | + [51,52] | +++ [57] | ++ [58,59] | + [62] |
| Cost | +++ | + | ++ | + | + |
a
The data for chinchilla, gerbil and guinea pig models were adapted from Doyle, 1989 [49].
OM, otitis media; NTHi, nontypeable H. influenza; SP, S. pneumoniae; MC, M. catarrhalis; NA, not available.
−, absent; + to +++, minimal to highly significant.