Table 1.
Time-dependent conformational transition monitored by CD studies of Q8HQHQ8, Q12HQHQ12HQHQ12, Q22, Q42, and Q8PQPQ8
| Number of days | ||||||
| Peptides | 10 | 20 | 30 | 40 | 50 | 60 |
| Q8HQHQ8 | U.O | U.O | U.O | U.O | U.O | β |
| Q12HQHQ12HQHQ12 | U.O | U.O | U.O | β | β | β |
| Q22 | U.O | β | β | β | β | β |
| Q42 | β | β | β | β | β | β |
| Q8PQPQ8 | U.O | U.O | U.O | U.O | U.O | U.O |
U.O = unordered; β = β structure.
The experimental observations indicate that in the same concentration range Q42 and Q22 undergo a transition from unordered to β conformation in a relatively much shorter period of time as compared to Q12HQHQ12HQHQ12.