Table 3.
Comparison of EC50 values from dose-response functions for miscellaneous odorants, beginning with n-alcohols, among various recent studies.
| Odorant | Species | Stimulus Phase | Response Level | Receptor(s) Tested | Fitting Model | EC50 (nM) | Reference |
|---|---|---|---|---|---|---|---|
| Ethanol | Human | Vapor | Behavioral | All | Eq. (2) | 13 | This study |
| Ethanol | Human | Vapor | Behavioral | All | Log normal | 3.7 | (Cain WS et al., 2005) |
| 1-Butanol | Human | Vapor | Behavioral | All | Eq. (2) | 0.32 | This study |
| 1-Butanol | Human | Vapor | Behavioral | All | Eq. (2) | 15 | (Cometto-Muñiz JE et al., 1999) |
| 1-Butanol | Fly | Vapor | Antenna | Or22a | Eq. (6) | 22,484 | (Pelz D et al., 2006) |
| 1-Butanol | Fly | Vapor | Antennal Lobe | Or22a | Eq. (6) | 2,657 | (Pelz D et al., 2006) |
| 1-Hexanol | Human | Vapor | Behavioral | All | Eq. (2) | 0.33 | This study |
| 1-Hexanol | Fly | Vapor | Antennal Lobe | Or22a | Eq. (6) | 816 | (Pelz D et al., 2006) |
| 1-Heptanol | Fly | Vapor | Antennal Lobe | Or22a | Eq. (6) | 347 | (Pelz D et al., 2006) |
| 1-Octanol | Human | Vapor | Behavioral | All | Eq. (2) | 0.18 | This study |
| 2-Heptanone | Human | Vapor | Behavioral | All | Eq. (2) | 3.0 | (Cometto-Muñiz JE et al., 1999) |
| Butyl acetate | Human | Vapor | Behavioral | All | Eq. (2) | 0.0041 | (Cometto-Muñiz JE et al., 2002) |
| Butyl acetate | Human | Vapor | Behavioral | All | Eq. (2) | 0.086 | (Cometto-Muñiz JE et al., 2003a) |
| Ethyl propanoate | Human | Vapor | Behavioral | All | Eq. (2) | 12 | (Cometto-Muñiz JE et al., 2005) |
| Ethyl heptanoate | Human | Vapor | Behavioral | All | Eq. (2) | 1.7 | (Cometto-Muñiz JE et al., 2005) |
| TXIB* | Human | Vapor | Behavioral | All | Log normal | 0.049 | (Cain WS et al., 2005) |
| D-Limonene | Human | Vapor | Behavioral | All | Log normal | 0.61 | (Cain WS et al., 2007b) |
| Toluene | Human | Vapor | Behavioral | All | Eq. (2) | 4.0 | (Cometto-Muñiz JE et al., 2002) |
| Toluene | Human | Vapor | Behavioral | All | Eq. (2) | 0.26 | (Cometto-Muñiz JE et al., 2003a) |
| Helional | Human | Liquid | Cell (HEK293) | h-OR17-40 | Eq. (3) | 98,700 | (Jacquier V et al., 2006) |
| Helional | Human | Liquid | Cell (HEK293) | h-OR17-40-EGFP | Eq. (3) | 114,400 | (Jacquier V et al., 2006) |
| Helional | Human | Liquid | Cell (HeLa/Olf) | Rho-tag(39)-Olfr43 | Eq. (5) | 3,600 | (Shirokova E et al., 2005) |
| (−) Citronellal | Human | Liquid | Cell (HeLa/Olf) | Rho-tag(39)-Olfr43 | Eq. (5) | 2,100 | (Shirokova E et al., 2005) |
| (−) Citronellal | Liquid | Cell (HeLa/Olf) | Rho-tag(39)-Olfr49 | Eq. (5) | 3,300 | (Shirokova E et al., 2005) | |
| (−) Citronellal | Liquid | Cell (HeLa/Olf) | Rho-tag(39)-MOR267-1 | Eq. (5) | 8,200 | (Shirokova E et al., 2005) | |
| Octanal | Human | Liquid | Cell (HeLa/Olf) | Rho-tag(39)-Olfr43 | Eq. (5) | 22,500 | (Shirokova E et al., 2005) |
| Glutaraldehyde | Human | Vapor | Behavioral | All | Log normal | 0.012 | (Cain WS et al., 2007a) |
| E-4-Decenal | Human | Liquid | Cell (HeLa/Olf) | Rho-tag(39)-Olfr43 | Eq. (5) | 30,400 | (Shirokova E et al., 2005) |
| Lilal | Human | Liquid | Cell (HEK293) | h-OR17-40 | Eq. (3) | 63,900 | (Jacquier V et al., 2006) |
| Lilal | Human | Liquid | Cell (HEK293) | h-OR17-40-EGFP | Eq. (3) | 124,100 | (Jacquier V et al., 2006) |
| Foliaver | Human | Liquid | Cell (HEK293) | h-OR17-40 | Eq. (3) | 96,700 | (Jacquier V et al., 2006) |
| Foliaver | Human | Liquid | Cell (HEK293) | h-OR17-40-EGFP | Eq. (3) | 145,400 | (Jacquier V et al., 2006) |
| Cyclosal | Human | Liquid | Cell (HEK293) | h-OR17-40 | Eq. (3) | 112,300 | (Jacquier V et al., 2006) |
| Cyclosal | Human | Liquid | Cell (HEK293) | h-OR17-40-EGFP | Eq. (3) | 142,900 | (Jacquier V et al., 2006) |
| Aldehyde TPM | Human | Liquid | Cell (HEK293) | h-OR17-40 | Eq. (3) | 113,300 | (Jacquier V et al., 2006) |
| Aldehyde TPM | Human | Liquid | Cell (HEK293) | h-OR17-40-EGFP | Eq. (3) | 139,500 | (Jacquier V et al., 2006) |
| Methyl-hydro-cinnamaldehyde | Human | Liquid | Cell (HEK293) | h-OR17-40 | Eq. (3) | 163,200 | (Jacquier V et al., 2006) |
| Methyl-hydro-cinnamaldehyde | Human | Liquid | Cell (HEK293) | h-OR17-40-EGFP | Eq. (3) | 168,000 | (Jacquier V et al., 2006) |
| Methyl-phenyl-pentanal | Human | Liquid | Cell (HEK293) | h-OR17-40 | Eq. (3) | 157,000 | (Jacquier V et al., 2006) |
| Methyl-phenyl-pentanal | Human | Liquid | Cell (HEK293) | h-OR17-40-EGFP | Eq. (3) | 158,500 | (Jacquier V et al., 2006) |
| Trifernal | Human | Liquid | Cell (HEK293) | h-OR17-40 | Eq. (3) | 154,600 | (Jacquier V et al., 2006) |
| Trifernal | Human | Liquid | Cell (HEK293) | h-OR17-40-EGFP | Eq. (3) | 120,300 | (Jacquier V et al., 2006) |
| Compound 2 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 175,000 | (Katada S et al., 2005) | |
| Compound 3 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 71,000 | (Katada S et al., 2005) | |
| Compound 4 (Eugenol) | Mouse | Liquid | Cell (HEK293) | mOR-EG | 47,000 | (Katada S et al., 2005) | |
| Eugenol | Mouse | Vapor | Glomerulus Ea | mOR-EG | 6.5 | (Oka Y et al., 2006) | |
| Eugenol | Mouse | Vapor | Glomerulus Eb | mOR-EG | 14 | (Oka Y et al., 2006) | |
| Eugenol | Mouse | Vapor | Glomerulus Ec | mOR-EG | 26 | (Oka Y et al., 2006) | |
| Eugenol | Mouse | Vapor | cell (HEK293) | mOR-EG | 46,000 | (Oka Y et al., 2006) | |
| Eugenol | Mouse | Vapor | Isolated OSNs | mOR-EG | 51,000 | (Oka Y et al., 2006) | |
| Eugenol | Mouse | Vapor | Glomerulus | 59 | (Oka Y et al., 2006) | ||
| Eugenol | Mouse | Liquid | Cell (HEK293T) | mOR-EG | Hill equation | 46,000 | (Kajiya K et al., 2001) |
| Compound 5 (Vanillin) | Mouse | Liquid | Cell (HEK293) | mOR-EG | 26,000 | (Katada S et al., 2005) | |
| Vanillin | Mouse | Vapor | Cell (HEK293) | mOR-EG | 26,000 | (Oka Y et al., 2006) | |
| Vanillin | Mouse | Vapor | Isolated OSNs | mOR-EG | 33,000 | (Oka Y et al., 2006) | |
| Vanillin | Mouse | Liquid | Cell (HEK293T) | mOR-EG | Hill equation | 36,000 | (Kajiya K et al., 2001) |
| Vanillin | Mouse | Liquid | Cell (HEK293T) | mOR-EV | Hill equation | 930,000 | (Kajiya K et al., 2001) |
| Ethyl vanillin | Mouse | Liquid | Cell (HEK293T) | mOR-EG | Hill equation | 290,000 | (Kajiya K et al., 2001) |
| Ethyl vanillin | Mouse | Liquid | Cell (HEK293T) | mOR-EV | Hill equation | 440,000 | (Kajiya K et al., 2001) |
| Compound 7 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 660,000 | (Katada S et al., 2005) | |
| Compound 8 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 160,000 | (Katada S et al., 2005) | |
| Compound 10 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 41,000 | (Katada S et al., 2005) | |
| Compound 11 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 57,000 | (Katada S et al., 2005) | |
| Compound 15 (4-hydroxy-3-methylbenzaldehyde) | Mouse | Liquid | Cell (HEK293) | mOR-EG | 4,000 | (Katada S et al., 2005) | |
| Compound 16 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 215,000 | (Katada S et al., 2005) | |
| Compound 17 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 33,000 | (Katada S et al., 2005) | |
| Compound 18 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 47,000 | (Katada S et al., 2005) | |
| Compound 19 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 68,000 | (Katada S et al., 2005) | |
| Compound 22 | Mouse | Liquid | Cell (HEK293) | mOR-EG | 26,000 | (Katada S et al., 2005) | |
| Methyl isoeugenol (MIEG) | Mouse | Vapor | Glomerulus Ea | mOR-EG | 3.3 | (Oka Y et al., 2006) | |
| Methyl isoeugenol (MIEG) | Mouse | Vapor | Glomerulus Ma | mOR-EG | 2.3 | (Oka Y et al., 2006) | |
| Methyl isoeugenol (MIEG) | Mouse | Vapor | Cell (HEK293) | MOR204-34 | 21,000 | (Oka Y et al., 2006) | |
| Acetic acid | Human | Vapor | Behavioral | All | Log odds ratio (Eq. (7)) | 0.094 | (Wise PM et al., 2007) |
| Butyric acid | Human | Vapor | Behavioral | All | Log odds ratio (Eq. (7)) | 0.0041 | (Wise PM et al., 2007) |
| Isovaleric acid | Mouse | Vapor | Glomerulus Ia | mOR-EG | 97 | (Oka Y et al., 2006) | |
| Hexanoic acid | Human | Vapor | Behavioral | All | Log odds ratio (Eq. (7)) | 0.041 | (Wise PM et al., 2007) |
| Octanoic acid | Human | Vapor | Behavioral | All | Log odds ratio (Eq. (7)) | 0.080 | (Wise PM et al., 2007) |
| Octanedioic acid | Mouse | Liquid | Cell (Xenopus oocyte) | MOR42-3 | Eq. (4) | 146,000 | (Abaffy T et al., 2006) |
| Nonanoic acid | Human | Liquid | Cell (HeLa/Olf) | Ors86 | Eq. (5) | 3,300 | (Shirokova E et al., 2005) |
| Nonanedioic acid | Mouse | Liquid | Cell (Xenopus oocyte) | MOR42-3 | Eq. (4) | 5,900 | (Abaffy T et al., 2006) |
| Nonanedioic acid | Human | Liquid | Cell (HeLa/Olf) | Ors6 | Eq. (5) | 500 | (Shirokova E et al., 2005) |
| Decanedioic acid | Mouse | Liquid | Cell (Xenopus oocyte) | MOR42-3 | Eq. (4) | 47,000 | (Abaffy T et al., 2006) |
| Decanedioic acid | Mouse | Liquid | Cell (Xenopus oocyte) | MOR42-1 | Eq. (4) | 6,500 | (Abaffy T et al., 2006) |
| Undecanedioic acid | Mouse | Liquid | Cell (Xenopus oocyte) | MOR42-1 | Eq. (4) | 63,000 | (Abaffy T et al., 2006) |
| Dodecanedioic acid | Mouse | Liquid | Cell (Xenopus oocyte) | MOR42-1 | Eq. (4) | 36,000 | (Abaffy T et al., 2006) |
In all equations, EC50 = odorant concentration producing half maximal response
*
TXIB: 2,2,4-trimethyl-1,3-pentanediol diisobutyrate
Eq. (2): P = Pmax/(1 + e^(−(x−C)/D)) where P= detection probability corrected for chance, Pmax = 1, x = odorant concentration, C = log EC50, and D: constant (function steepness)
Eq. (3): F(x) = m0 + ((m1 × (x^n))/(C^n + x^n) where m0 = minimum, m1 = maximum, x = odorant concentration, C = EC50, and n = Hill coefficient
Eq. (4): I = Imax/(1 + (EC50/X)^n) where I = current response, Imax = maximal current response, X = odorant concentration, and n = apparent Hill coefficient
Eq. (5): F(x) = (a − d)/(1 + (x/C)^n) + d where a = minimum, d = maximum, x = odorant concentration, C = EC50, and n = Hill coefficient
Eq. (6): R(x) = Rmax (x^n/EC50^n + x^n) where R = maximal response, x = odorant concentration, n = Hill coefficient
Eq. (7): ln{p/(1−p)} = a.x + b, where p = chance-corrected proportion correct detection, x = odorant concentration, a = constant, b = slope