Figure 7.
A complete sequence alignment of adenylosuccinate lyase from B. subtilis, T. maritima, and H. sapiens generated in Clustal W. These three proteins share 16% identity plus 21.3% high similarity and 15% weak similarity. Conserved residues are shown in white font with a black background, highly similar residues are in white font with a dark gray background, and weakly similar residues are in black front with a light gray background. The alignment numbering corresponds to that of the B. subtilis enzyme. The residues of particular interest, that is, Met10, Ile123, and Thr367 (B. subtilis numbering) are indicated by an asterisk (*) below the alignment.