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A semiquantitative model for a structure-based PI resistance assay. Distributions of calculated ΔEbind for PR variants phenotypically sensitive and resistant to six PIs were used to define the binding energy cutoffs c1 and c2 for prediction of sensitivity (S) or resistance (R) to each PI, respectively. Cases c1 ≤ ΔEbind ≤ c2 are considered equivocal (E).
