Table 2.

Regression analysis of calculated ΔE_bind and experimental changes in binding energy^a

A: ViroLogic PhenoSense
Inhibitor	N	R2	S.E. (kcal/mole)	S.E. (fold)b
Amprenavir	65	0.83	0.36	1.8
Indinavir	65	0.80	0.43	2.0
Lopinavir	48	0.81	0.46	2.1
Nelfinavir	65	0.76	0.50	2.3
Ritonavir	65	0.78	0.57	2.5
Saquinavir	65	0.83	0.45	2.1

B: Virco Antivirogram
Inhibitor	N (outliers)c	R2 (+outliers)	S.E. (+outliers)	S.E. (fold)b (+outliers)
a Experimental changes in the binding energy were estimated as RT ln(IC50mut/IC50wt). The number of data points (N), correlation coefficients (R2), and standard errors (S.E.) in predicted binding energies are given.
b The standard error of prediction is expressed as a change in the fold resistance.
c Outliers are data points that were excluded to obtain statistically significant correlations. Characteristics of correlations obtained with outliers are given in parentheses.
Amprenavir	63 (6)	0.53 (0.34)	0.42 (0.55)	2.0 (2.4)
Indinavir	63 (8)	0.72 (0.51)	0.43 (0.57)	2.0 (2.5)
Lopinavir	63 (3)	0.81 (0.70)	0.35 (0.44)	1.8 (2.0)
Nelfinavir	63 (2)	0.70 (0.57)	0.47 (0.58)	2.1 (2.6)
Ritonavir	63 (3)	0.78 (0.68)	0.54 (0.68)	2.4 (3.0)
Saquinavir	61 (5)	0.66 (0.37)	0.56 (0.77)	2.5 (3.5)