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Electrostatic properties of the homology models of the N-terminal PLCγ PH isoforms. The Cα backbone traces of the models for γ1-PH (A, C) and γ2-PH (B, D) without (A, B) and with (C, D) bound Ins(1,3,4,5)P4 (yellow spheres) are depicted. The electrostatic potentials were calculated and visualized in GRASP (Nicholls et al. 1991). The blue and red meshes represent, respectively, the +1 kT/e and −1 kT/e equipotential contours for 0.1 M KCl.
