Figure 12.

Sequence assignment of the split PLCγ PH domains. The top portion of the figure shows the two alternative domain architectures assigned to PLCγ by the SMART database (Schultz et al. 1998). This arrangement indicates that the location of the second PH domain overlaps with that of the SH3 domain. We predict that the two halves of the domain are located in the regions between (1) the X portion of the catalytic domain and the first SH2 domain (gray arrows) and (2) the SH3 domain and the Y portion of the catalytic domain (black arrows). The sequence segments that are combined to comprise our prediction for the sequence of the PLCγ1 PH domain are highlighted in purple.