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Sequence alignment of p130-PH and PLCδ1-PH. Conserved residues are represented as white letters on a black background. Residues of the PLCδ1 PH domain that make direct contacts with Ins(1,4,5)P3 are highlighted in orange. Hydrophobic residues (Val, Met) that may contribute to the membrane partitioning of PLCδ1-PH are highlighted in green.
