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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Prog Neurobiol. 2007 Nov 26;84(2):116–131. doi: 10.1016/j.pneurobio.2007.11.003

Fig. 2.

Fig. 2

Roles of CXCL12/CXCR4 in brain development. The cartoon shows a schematic view of developing mouse brain (E12.5 and E15). CXCL12/CXCR4 regulates the migration of neuronal precursors during early brain development. (A) At embryonic day 12.5 (E12.5), CXCR4+ Cajal-Retzius (CR) cells are generated from the ventricular zone (VZ) near the lateral ventricle (LV) of the telencephalon and migrate to the marginal zone (MZ) through short range radial migration (blue arrow). CXCR4+ CR cells further spread to the whole telencephalon through long range tangential migration (yellow arrow). CXCL12 secreted from the meninges (dashed red line) is required for the migration of CR cells; (B) In E15 hippocampus, CXCR4+ dentate precursors are generated from subventricular zone (SVZ) near the lateral ventricle (LV). CXCL12 secreted from the meninges (dashed red line) guides the migration (blue line) of dentate precursors to the dentate gyrus (DG); (C) In E15 cerebellum, CXCR4+ granule cell precursors that are generated from the subventricular zone (SVZ) of rhombic lip (RL) migrate tangentially (yellow arrow) to cover most of the cerebellar surface forming the external granule cell layer (EGL). CXCL12 (dashed red line) secreted from meninges maintains cell proliferation and prevents premature exit of granular cell precursors from the EGL.

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