Table 3.
Impact of Diabetes “Risk Factors” on RPG AROC to Detect Diabetes; Likelihood of RPG > 125 mg/dl, and Likelihood of Diabetes or Any Glucose Intolerance110
| Group | AROC | 95% CI | Number of patients | Likelihood of RPG >125 OR (95% CI) | Likelihood of diabetes | Likelihood of any glucose intolerance110 |
|---|---|---|---|---|---|---|
| All | 0.805 | 0.746–0.864 | 989 | |||
| Black | 0.834 | 0.761–0.906 | 517 | 0.56 (0.36–0.87) | 1.39 (0.78–2.46) | 1.23 (0.92–0.165) |
| White | 0.776 | 0.675–0.876 | 472 | |||
| Female | 0.833 | 0.759–0.907 | 652 | 0.60 (0.39–0.93) | 0.50 (0.33–1.04) | 0.68 (0.50–0.92) |
| Male | 0.751 | 0.646–0.855 | 337 | |||
| Age, <40 | 0.807 | 0.632–0.981 | 234 | 1.00 | 1.00 | 1.00 |
| Age, 40–55 | 0.734 | 0.614–0.855 | 460 | 1.96 (1.02–3.74) | 1.86 (0.71–4.90) | 2.53 (1.59–4.03) |
| Age, >55 | 0.837 | 0.764–0.910 | 295 | 2.33 (1.19–4.57) | 4.60 (1.70–15.50) | 4.66 (2.90–7.50) |
| BMI, <25 | 0.782 | 0.651–0.913 | 221 | 1.00 | 1.00 | 1.00 |
| BMI, 25–35 | 0.782 | 0.670–0.895 | 542 | 1.36 (0.75–2.47) | 2.31 (0.82–6.47) | 3.14 (1.95–5.05) |
| BMI, >35 | 0.809 | 0.732–0.887 | 226 | 1.71 (0.83–3.30) | 6.47 (2.16–26.03) | 4.70 (2.80–7.86) |
| Trig, >150 | 0.698 | 0.533–0.862 | 129 | 1.80 (1.04–3.12) | 1.96 (0.99–3.90) | 2.55 (1.73–3.75) |
| Trig, <150 | 0.821 | 0.756–0.886 | 860 | |||
| HDL low | 0.798 | 0.718–0.877 | 454 | 1.35 (0.88–2.09) | 1.82 (1.03–3.24) | 1.99 (1.48–2.68) |
| HDL normal | 0.812 | 0.722–0.902 | 535 | |||
| Family Hx+ | 0.792 | 0.714–0.870 | 487 | 1.66 (1.07–2.59) | 2.27 (1.25–4.14) | 1.63 (1.22–2.20) |
| Family Hx− | 0.814 | 0.725–0.903 | 502 | |||
| SBP, >130 | 0.804 | 0.703–0.905 | 239 | 1.77 (1.12–2.79) | 2.69 (1.52–4.76) | 1.99 (1.45–2.73) |
| SBP, <130 | 0.797 | 0.721–0.873 | 750 | |||
| Waist+ | 0.805 | 0.742–0.868 | 736 | 1.15 (0.74–1.77) | 3.40 (1.78–6.78) | 3.04 (2.22–4.17) |
| Waist− | 0.672 | 0.431–0.914 | 253 |
To assess the performance of RPG in subgroups with different pretest probability of glucose intolerance, we examined detection of diabetes/AGT110 in groups with differences in risk factors such as age, BMI, family history of diabetes in a first-degree relative, etc. For each subgroup, shown are the likelihood of having RPG > 125 mg/dl, the likelihood of diabetes/dysglycemia, and AROC for detection of diabetes. With regard to the black race, many blacks were female and had a family history of diabetes in a first-degree relative. In our dataset, women were somewhat less likely to fail the cutoff or to have glucose intolerance; in multivariate analyses adjusted for age, BMI, gender, and family history, black race contributed independently to the risk of the different categories of glucose intolerance (all p < 0.03) and also to risk of having RPG > 125 (p = 0.012).