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. 2008 May;56(5):433–441. doi: 10.1369/jhc.7A7359.2008

Figure 1.

Figure 1

Proliferation zone–associated expression. (A) Strong staining of the 70-kDa heat shock protein (HSP70) RNA in a multiple intestinal neoplasia (Min) colonic adenoma and in the proliferation zone of adjacent normal crypts. (B) Negative control of A with sense probe. (C) Elevated staining of HSP70 RNA in a Min adenoma from the small intestine and in the proliferation zone of adjacent normal crypts. (D) Strong staining of HSP70 in a colonic tumor induced by azoxymethane (AOM). (E) Immunostaining showing strong production of HSP70 protein in a human colonic adenoma. (F) Apparent IHC signal of HSP70 protein in the lower part of normal epithelial crypts. (G) Strong RNA signal of stathmin1 in a Min colonic tumor. (H) Strong signal of CD24a in a Min colonic tumor indicated by ISH. Bar = 200 μm.