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. 2008 May;56(5):433–441. doi: 10.1369/jhc.7A7359.2008

Figure 3.

Figure 3

Tumor-associated expression. (A) Strong ISH signal of MARCKS-like protein (MLP) RNA in a Min colonic adenoma but not in the adjacent normal crypts. (B) Negative control of A with sense probe. (C) Elevated ISH signal of MLP RNA in a Min adenoma from the small intestine. (D) Elevated ISH signal of MLP RNA in a colonic tumor induced by AOM (inset: adjacent normal epithelium at the same magnification). (E) Immunostaining showing strong production of MLP antigen in a human colonic adenoma. (F) Absence of MLP antigen in the normal human colonic epithelium. (G) Tumor-associated ISH signal of clusterin RNA in a Min colonic adenoma. (H) Strong ISH signal of Wnt-inhibitory factor 1 (WIF-1) RNA within a Min colonic adenoma but not in the adjacent normal epithelium. Bar = 200 μm.