Table 4.

Distribution of signs and symptoms according to the checklist with dihydropyridines given at high doses

Signs/symptoms	Global (%)	Lercanidipine (%)	Amlodipine/ nifedipine (%)	p
Ankle oedema	46.9	42.9	55.8	0.007
Flushes	33.8	28.3	46.2	< 0.001
Headache	32.0	27.5	42.3	0.002
Swelling	30.9	25.8	42.3	< 0.001
Fatigue	19.3	15.9	26.9	0.01
Dizziness	16.0	14.2	20.2	ns
Palpitations	14.2	10.7	22.1	0.006
Constipation/diarrhoea	13.9	10.3	22.1	0.005
Pyrosis	11.3	8.6	17.3	0.02
Sexual dysfunction	10.4	8.2	15.4	0.04
Dyspnoea	9.8	7.7	14.4	ns
Blurred vision	9.2	8.2	11.5	ns
Skin rush	8.0	4.7	15.4	0.001
Thoracic pain	5.3	6.0	3.8	ns
Gum swelling	2.4	1.7	3.8	ns
Thoracic swelling	1.8	1.3	2.9	ns

ns, not significant (p > 0.05).