Figure 1.

FIV-specific suppressor activity in acutely infected cats. Mitogen-activated lymphoblasts were prepared from the blood (PBMC; a and b), lymph nodes (LNC; c and d), and spleen (e and f) of three cats, 12 weeks postinfection with FIV_PET, and were cocultured with either FIV_PET-infected (▪) or FIV_GL-8-infected (•) MYA-1 cells at ratios of 4:1 (---), 2:1 (– – –), and 1:1 (· · ·). Control cultures contained FIV-infected MYA-1 cells alone (——). Replication of FIV was indicated by the detection of viral p24 in the culture supernatant by ELISA. The results shown represent the OD values at 650 nm for the lymphoid tissues of each individual cat. Control cultures with FIV-infected MYA-1 cells were performed in duplicate, and are represented as the mean OD values at 650 nm for the three cats ± 2 SD, error bars are not discernible where the SD is small.