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. 1999 Mar;96(3):358–364. doi: 10.1046/j.1365-2567.1999.00712.x

Figure 2.

Figure 2

The production of IFN-γ, IL-4, IL-10 and IL-13 by non-adherent SFMC from seven patients with RA and by non-adherent PBMC from five healthy volunteers after in vitro treatment with different cytokines. The cells were cultured for 12 days in the presence of IL-2 alone (control) or in the presence of IL-2+IL-4 (left two panels), IL-2+IL-12 (middle), or IL-2+IL-10 (right). The effects of IL-10 were studied in six patients with RA and in four healthy volunteers. Cultured cells were activated for 24 hr in the presence of IL-2 (100 U/ml), anti-CD3 mAb (1 μg/ml) and anti-CD28 mAb (10 μg/ml) and the production of cytokines was studied using specific ELISA. The dots represent individual samples and the lines connect cytokine production in the presence of IL-2 alone and in the presence of IL-2 + the cytokine tested. An asterisk denotes a significant difference (P < 0·05) from the control using Wilcoxon signed-rank test.