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Clonotype-specific mAb induce anergy in human Th1-clone H.243. Immobilized anticlonotype mAb or control mAb ZP 7A were incubated overnight with H.243 T cells. After removal of the cells from the anergic stimulus, the cells were challenged with a full stimulus of increasing concentrations of peptide in the presence of DRB1*0401-matched APC. Proliferation was assessed by [3H]thymidine incorporation. Each value represents the mean counts per 5 min (c.p.5m.) of triplicate cultures ±SD.
