Figure 2.

Effect of the anti-rat α₄ integrin mAb TA2 on PAF- and LTB₄-induced ¹¹¹In-eosinophil accumulation in rat skin. Animals were pretreated with TA2 (5 mg/kg i.v.) or MOPC-21 (control, 5 mg/kg i.v.) 15 min prior to the i.v. administration of ¹¹¹In-eosinophils. (a) PAF or (b) LTB₄ were administered intradermally and the responses were quantified 4 hr later as detailed in the Materials and Methods. The results, which have been corrected for the small level of counts in Tyrode-injected sites, are expressed as mean±SEM (n = at least seven pairs of rats). Significant differences in responses detected between MOPC-21-treated and TA2-treated rats are shown by asterisks; *P < 0·05 and **P < 0·01.