Figure 4.
Effect of locally administered actinomycin D on (a) PAF- or (b) LTB4-induced 111In-eosinophil accumulation in rat skin. PAF and LTB4 (both at 10−10 mol/site) were injected intradermally with or without actinomycin D (5×10−9 m/site) at −3 hr, −1 hr, −0·5 hr and 0 hr prior to the i.v. administration of 111In-eosinophils. After a 1-hr accumulation period, 111In-eosinophil accumulation/site was quantified as detailed in the Materials and Methods. The results, which have been corrected for the small level of counts detected in corresponding Tyrode/actinomycin D-injected skin sites, are mean±SEM for n = at least five pairs of rats.