Figure 4.

Number of granulocytes in peripheral blood of naive, cyclophosphamide-treated mice and irradiated mice whether or not treated with G-CSF before infection and at 4 and 24 hr after infection with S. aureus in these mice. Mice were treated with cyclophosphamide or irradiated, thereafter treated with G-CSF or vehicle for 4 days and subsequently infected with 5×10⁶ bacteria in the thigh muscle. Values are mean and sd of 4–10 mice at each time-point. **significant difference comparing G-CSF-treated with non-G-CSF-treated (P <0·01); *significant difference comparing G-CSF-treated with non-G-CSF-treated (P <0·05); †significant different relative to naive mice (P <0·05).