Table 2.

Proliferation of bone-marrow cells from naive, cyclophosphamide-treated and irradiated mice treated with G-CSF and infected with S. aureus†

†Mice were treated with cyclophosphamide or irradiated, then treated with G-CSF or vehicle for 4 days and subsequently either or not infected with 5 × 10₆ S. aureus in the thigh muscle. Before infection and at 4 and 24 hr after infection, bone-marrow cells from the mice were isolated and 1 × 10₄ bone marrow were cultured for 7 days in triplicate, then the total number of cells present and the number of granulocytes were determined. Values are mean (SD) of three mice at each time-point.

‡After 7 days of culture granulocyte precursors are differentiated into mature granulocytes.

§Significant difference relative to naive mice (P < 0·05).

**Significant difference comparing G-CSF-treated with non-G-CSF-treated (P < 0·01).

*Significant difference comparing G-CSF-treated with non-G-CSF-treated; (P < 0·05).