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Decreased levels of IL-12 production in macrophages exposed to sulfasalazine in vivo. Mice were treated in vivo with sulfasalazine (1 mg, i.p.). After 24 hr, macrophages were purified and stimulated with LPS or HKL. Culture supernatants were harvested 48 hr later and IL-12 content was assayed by ELISA. The values represent the mean±SD of triplicate determinations of three separate experiments.
