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Calcium mobilization in A549 cells following chemokine stimulation. 2 μg/ml SDF-1α (a) produced a rapid and robust calcium mobilization whilst 2 μg/ml IL-8 (b) did not. In each experiment bradykinin 100 nm was used as a positive control to check epithelial cell integrity. These results indicate that epithelial expressed CXCR4 can couple to G-protein-linked signal transduction mechanisms.
