Table 2.

The role of complement receptor type 2 (CR2) on B cells and follicular dendritic cells (FDC) in the development of a humoral immune response

		Immune response
Chimera construction memory	Cell phenotype	Primary Abresponse	Class switchresponse	Long-termresponse	IgG response
Cr2–/– es cellsin	CR2– B cells+	↓	↓	↓	↓
RAG-2–/– blastocytes	CR2+ FDC
Cr2+/+ BM cellsin	CR2+ B cells+	Normal	Normal	↓	↓
irradiated Cr2–/– mice	CR2– FDC

BM, bone marrow, es cells, embryonic stem cells; FDC, follicular dendritic cells; RAG-2, recombination-activating gene-2; ↓, decreased.