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. 2000 Sep;101(1):61–67. doi: 10.1046/j.1365-2567.2000.00082.x

Figure 3.

Figure 3

Effect of human calcitonin gene-related peptide 8–37 (hCGRP8−37) on CGRP-diminished interleukin-12 (IL-12) release from mouse peritoneal macrophages (Mφ). hCGRP8−37 (5 µm), an antagonist of the CGRP1 receptor, was added to Mφ 15 min before 100 nm CGRP, and stimulation with 0·1 µg/ml of lipopolysaccharide (LPS) was carried out for 24 hr. The IL-12 level in the medium was assayed by using an enzyme-linked immunosorbent assay (ELISA). The effect of CGRP on IL-12 release was not abrogated by hCGRP8−37. The data shown represent the mean value ± SEM, n = 6 for each group.