Figure 5.
Host-derived 4-1BBL are involved in the eradication of NRS1 tumours at the secondary challenge. C3H mice in groups of 10 were immunized with irradiated NRS1 cells by s.c. injection of 5 × 106 cells. After 30 days, live NRS1 cells (5 × 105 cells/mouse) were injected s.c. and 100 µg each of control rat immunoglobulin, anti-4-1BBL, anti-CD80, anti-CD86, or both anti-CD80 and CD86 mAbs were administered i.p. every other day for 2 weeks. The results are expressed as tumour volume of each mouse. Tumour size was measured. The results are expressed as tumour volume of each mouse. Similar results were obtained in another independent experiment.