Figure 4.

Correlation of sL-selectin levels and HLA class II risk category (a) unaffected relatives of patients with type I diabetes and (b) healthy controls. sL-selectin levels increase progressively with increasing HLA determined genetic susceptibility. Category I contains relatives with no diabetes associated haplotypes, Categories II and III have at least one susceptibility haplotype with or without the protective DQB1*0602 allele, and Category IV contains relatives at highest risk who are heterozygous for DRB1*03-DQB1*0201/DRB1*04-DQB1*0302.