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Antigen dose-dependent H2 control of antibody levels to the recombinant 16 000-MW protein of Mycobacterium tuberculosis (rPT16). Mice were injected intraperitoneally (i.p.) with rPT16, first in Freund’s incomplete adjuvant (FIA) and 3 weeks later in saline. Symbols represent 7-day antibody titres (mean, n = 5, IgG ABT30 ± SD, vertical bars) in B10.BR (squares), (B10.BR × B10)F1 (triangles) and B10 (circles) mice.
