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. 2008 Apr 1;27(7):1722–1730. doi: 10.1111/j.1460-9568.2008.06162.x

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© The Authors (2008). Journal compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd

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Fig. 5 — Intrathalamic administration of the CB₂ receptor agonist JWH-133 inhibited (A) innocuous and (B) noxious mechanically evoked responses of VPL thalamic neurons in SNL rats but not sham-operated rats. JWH-133 (30 ng in 500 nL) was administered intra-VPL, alone or in combination with the CB₂ receptor antagonist SR144528 (48 ng) or the CB₁ receptor antagonist AM251 (48 ng) in sham-operated and SNL rats. Innocuous (7 g) and noxious (65 g) mechanically evoked responses were recorded at 15 and 30 min after drug administration, respectively. Data were analysed using the Kruskall–Wallis test followed by Dunn's post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001 vs. pooled vehicle; ^###P < 0.001 vs. SNL: JWH-133; ^$$P < 0.01 vs. Sham: JWH-133 (n = 46–115 neurons in five or six rats per data set). Vehicle treatment data from sham and SNL rats were not statistically different and were pooled for clarity of presentation.