Table 4.
Patient outcomes based on bolus corticosteroid usage1
| No steroid (n = 16) | Steroid ≤D12 (n = 7) | Steroid >D12 (n = 7) | P | P, early vs. late CS | |
|---|---|---|---|---|---|
| ES: M/S/mM/mS, n2 | 5/2/5/3 | 4/4/6/6 | 5/2/6/6 | NA | NA |
| Weight change, % | 0.6 (0.42–6.7) | 6.7 (3.6–27.2) | 11.2 (–2.1 to–23.2) | 0.005 | NS |
| Rash, % | 27 | 71 | 43 | NS | NS |
| Diarrhea, % | 73 | 86 | 86 | NS | NS |
| Tmax, °C | 39 (37.8–41) | 40.1 (39–41.1) | 38.9 (38.7–40.8) | 0.08 | 0.07 |
| 1st fever, day | 10 (6–15) | 8 (7–9) | 12 (8–146) | 0.007 | 0.007 |
| Abnormal CXR1, % | 13 | 71 | 71 | 0.03 | NS |
| Ventilator, % | 0 | 14 | 71 | 0.004 | 0.03 |
| First WBC, day | 12 (8–21) | 14 (12–14) | 14 (12–17) | 0.03 | NS |
| ANC500, day | 15 (12–29) | 16 (14–115) | 18 (15–45) | 0.08 | NS |
| PLT20, day | 12 (8–41) | 20 (11–115) | 24 (9–170) | 0.05 | NS |
| PLT50, day | 15 (11–192) | 32 (16–115) | 56 (13–551) | 0.03 | NS |
| RBCs, units | 3 (2–8) | 6 (4–31) | 11 (6–64) | 0.0008 | NS |
| PLTS, apheresis units | 2 (1–9) | 9 (4–51) | 18 (4–60) | 0.0004 | NS |
| Hospital dismissal, day | 15 (13–36) | 21 (15–69) | 41 (16–175) | 0.009 | 0.05 |
1
Except where stated otherwise, values are expressed as median (range).
2
ES, engraftment syndrome according to definition of Maiolino (11) (M), Spitzer (10) (S), modified Mailino (mM) and modified Spitzer (mS) – see text and Fig. 1 for definitions.
ANC500, absolute neutrophil count >0.5 × 109/L; PLT20, platelet engraftment to 20 × 109/L; PLT50, platelet engraftment to 50 × 109/L; RBCs, red blood cell transfusion; PLTS, platelet transfusions.