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. 2008 Mar 1;27(6):1345–1352. doi: 10.1111/j.1460-9568.2008.06109.x

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© The Authors (2008) Journal compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd

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Fig. 3 — Application of an mGluR1 antagonist prior to, but not after, LFS prevented LTD in the CA1 region. LFS (2 Hz, 1200 pulses) induced persistent LTD which lasted for at least 4 h in the CA1 region in vitro. Application of the mGluR1 antagonist LY367285 (100 µm), for 20 min prior to LFS, significantly impaired the induction and expression phases of LTD. Application of the mGluR1 antagonist LY367285 (100 µm) for 20 min after LFS had no effect on the profile of LTD. Bar indicates drug application before (black) or after (grey) LFS. Insets: evoked potentials obtained in the presence of LY387385 applied pre-HFT or LY387385 applied post-HFT at the timepoints noted: vertical bars, 2 mV; horizontal bars, 2 ms.