Skip to main content
. 2007 Sep 27;585(Pt 1):91–101. doi: 10.1113/jphysiol.2007.141531

Figure 4.

Figure 4

Ifenprodil sensitivity of extrasynaptic NMDARs in PCs from adult mice A, superimposed NMDAR channel openings in an outside-out patch from an adult PC exposed to 100 μm NMDA (50 μm glycine) before and after the application of 5 μm ifenprodil (P63; −60 mV). In this patch, ifenprodil reduced channel activity. B, bar plot of pooled data from 10 experiments showing that, on average, ifenprodil reduced the NMDAR charge transfer (Q(t)) to 63.7 ± 0.5% of control. Note that some patches (right hand bar) were unaffected by ifenprodil. Symbols indicate values from individual patches. Note that the scatter of the data was likely to be due to the presence of more than one NMDAR in each patch. Dotted lines indicate the level of inhibition expected for recombinant NR2A-, NR2A–NR2B- or NR2B-containing NMDAR, in the presence of 3 μm ifenprodil (see Hatton & Paoletti, 2005).