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. 2008 Apr;15(4):261–270. doi: 10.1101/lm.810208

Figure 1.

Figure 1.

Constitutively active Gαi2 does not alter input–output relations or paired-pulse facilitation at Schaffer collateral-CA1 synapses. (A) Input–output relation of Schaffer collateral-CA1 evoked EPSP slopes (percent maximum) as a function of stimulus intensity (μA) in Gαi2-expressing double-transgenic (●) versus pooled single-transgenic slices (◦). Each point is mean ± SEM of six slices. (B) Percent paired-pulse facilitation profiles (S2/S1) at Schaffer collateral-CA1 evoked EPSPs as a function of interstimulus interval in slices from Gαi2-expressing (●) and single-transgenic control (◦) mice. Each point is mean ± SEM of six slices. (C) Input–output relation of NMDA receptor-dependent evoked EPSP slopes (percent maximum) pharmacologically isolated by bath-applied CNQX (10 μM), in Gαi2-expressing double-transgenic (●) versus pooled single-transgenic slices (◦). Each point is mean ± SEM of six slices.