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Stimulus-evoked long-term potentiation (LTP) at Schaffer collateral-CA1 synapses is impaired in slices from mice expressing constitutively active Gαi2. Time course of experiments comparing theta burst-evoked LTP (arrow; 4× theta burst stimulation) at Schaffer collateral-CA1 synapses in slices from Gαi2-expressing double-transgenic (●; n = 12) versus pooled single-transgenic mice (◦; n = 15). Each point is mean ± SEM of n slices.
