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. 2008 Apr;15(4):261–270. doi: 10.1101/lm.810208

Figure 3.

Figure 3.

Stimulus-evoked long-term depression (LTD) at Schaffer collateral-CA1 synapses is enhanced in slices from mice expressing constitutively active Gαi2. (A) Time course of experiments comparing stimulus-evoked LTD (solid bar; 2 Hz/10 min) at Schaffer collateral-CA1 synapses in slices from Gαi2-expressing double-transgenic (●; n = 11) versus pooled single-transgenic control mice (◦; n = 14). Each point is mean ± SEM of n slices. (B) Time course of stimulus-evoked LTD (solid bar; 2 Hz/10 min) at Schaffer collateral-CA1 synapses in Gαi2-expressing double-transgenics 5 d after being taken off doxycycline (off Dox; ●; n = 11), compared with double transgenics where expression was suppressed by doxycycline (on Dox; ◦; n = 5). Each point is mean ± SEM of n slices. (C) Time course of stimulus-evoked LTD (solid bar; 2 Hz/10 min) at Schaffer collateral-CA1 synapses in slices from single-transgenic control mice (◦; n = 14), compared with slices from Gαi2-expressing double transgenics where expression remained blocked by doxycycline (on Dox; ●; n = 5). Each point is mean ± SEM of n slices.