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. 2008 Apr;15(4):261–270. doi: 10.1101/lm.810208

Figure 6.

Figure 6.

Constitutively active Gαi2 reduces frequency, but not amplitude or kinetics, of TTX-sensitive spontaneous mEPSCs, without altering TTX-insensitive mEPSCs. (A1) Sample mEPSCs recorded from CA1 pyramidal neurons voltage clamped at –55 mV in the absence of TTX. The top line is a representative segment of EPSC recordings from a pyramidal neuron in a slice from a single-transgenic control animal (ST), while the bottom is a similar representative segment from a slice from a Gαi2-expressing double-transgenic mouse (DT). (A2) Comparison of the mean ± SEM frequency (Hz), amplitude (pA), rise and decay times (ms) of mEPSCs in pyramidal neurons from single transgenic control (S) and Gαi2-expressing double transgenic (D) mice. Only frequency was significantly reduced by Gαi2 expression (*, P < 0.05, one-way ANOVA) (B1) Sample mEPSCs recorded from CA1 pyramidal neurons voltage clamped at –55 mV in the presence of 1 μM TTX. The top line is a representative segment of EPSC recordings from a pyramidal neuron in a slice from a single-transgenic control animal (ST-TTX), while the bottom is a similar representative segment from a slice from a Gαi2-expressing double-transgenic mouse (DT-TTX). (B2) Comparison of the mean ± SEM frequency (Hz), amplitude (pA), rise and decay times (ms) of mEPSCs in pyramidal neurons from single-transgenic (S) and Gαi2-expressing double-transgenic (D) mice.