Figure 2.

(A) The core of the S-836 consists of side chains of nonpolar amino acids. (B) In general, nonpolar amino acids (yellow) are buried and polar amino acids (blue) are exposed to solvent. (C) Nonpolar amino acids comprising the core exhibit well-defined structure. The figure shows nonpolar amino acids in the 15 lowest energy structures, with residues in helices 1 and 2 on the left and residues in helices 3 and 4 on the right. This well-ordered hydrophobic core indicates that S-836 forms a native-like structure.